If you want to configure your own proxy.pac file to, for example, do not modify the proxy configuration if you are in the office or later at home, we can create a new proxy.pac file and configure in the proxy setup in Internet Explorer with file://folder/with/proxy.pac, however, windows will ignore this file to avoid exactly what we are trying to achieve. See the Microsoft explanation about how Microsoft handles the Proxy configuration in https://blogs.msdn.microsoft.com/ieinternals/2013/10/11/understanding-web-proxy-configuration/
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